There are many health conditions that can damage your kidneys and lead to CKD and ESRD.

Glomerulonephritis

Glomerulonephritis (glow-mer-you-low-nef-RYE-tis), sometimes called glomerular disease, is a type of kidney disease in which the glomeruli are damaged and cannot remove waste and fluid like they should. Glomerulonephritis can begin suddenly or slowly, over time. Learn more about glomerulonephritis.

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Polycystic kidney disease (PKD)

There are two types of PKD: autosomal dominant PKD and autosomal recessive PKD. Autosomal dominant PKD causes cysts only in the kidneys. It is often called “adult PKD,” because people with this type of PKD might not notice any symptoms until they are between 30 and 50 years old. Autosomal recessive PKD causes cysts to grow in both the kidneys and the liver. Learn more about PKD.

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IgA nephropathy

IgA is a protein that helps you fight infections. In people with IgA nephropathy, these proteins build up and form clumps inside the kidneys’ tiny filters (glomeruli). These clumps of proteins damage the glomeruli. This damage can cause chronic kidney disease and can lead to kidney failure/ESRD. Learn more about IgA nephropathy.

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Lupus nephritis

Lupus nephritis (nef-RYE-tis) is the medical name for kidney swelling and irritation that is caused by lupus. Lupus is an autoimmune disease. Autoimmune diseases cause your immune system to attack your own healthy cells. When your immune system attacks your kidneys, they get damaged. The damage can be very serious. Learn more about lupus nephritis.

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Nephrotic syndrome

Nephrotic syndrome is a group of symptoms that, together, show that your kidneys are not working as well as they should. People with nephrotic syndrome usually have too much protein in their urine and not enough protein in their blood. They also have too much fat and cholesterol in their blood, and can have swelling in their legs, feet and ankles. Learn more about nephrotic syndrome.

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Kidney cancer

Kidney cancer is a type of cancer that starts in the kidneys. It can happen to people of all ages. The most common type of kidney cancer is called renal cell carcinoma, and it usually happens in adults. This type of kidney cancer starts in the tiny filters in your kidneys. Learn more about kidney cancer.

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Rare diseases

Some rare, or less common, diseases can cause kidney damage that leads to chronic kidney disease and kidney failure. Some of these rare diseases include: Alport syndrome; amyloidosis; Goodpasture syndrome; and Wegener’s granulomatosis. These disease may harm the kidneys, as well as other organs and tissues. Learn more about the rare diseases that affect the kidneys.

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