Alagille syndrome mainly affects your liver but can damage other parts of your body including your kidneys, heart, brain, eyes, and skeleton. Alagille syndrome is caused by a buildup of bile in your liver, causing scarring and damage. When your liver is damaged, certain wastes cannot be removed from your blood, which causes problems throughout your body, including damage to the kidneys. There is no cure for Alagille syndrome, but there are medicines that can help control it by removing bile from your liver.
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