Some rare, or less common, diseases can cause kidney damage that leads to chronic kidney disease and kidney failure. These disease may harm the kidneys, as well as other organs and tissues.
- Alagille syndrome
- Alport syndrome
- Fabry disease
- Focal segmental glomerulosclerosis (FSGS)
- Goodpasture syndrome
- aHUS (atypical hemolytic uremic syndrome)
- Hemolytic uremic syndrome (HUS)
- Henoch-Schönlein purpura
- IgA nephropathy (Berger’s disease)
- Interstitial nephritis
- Minimal change disease
- Nephrotic syndrome
- Thrombotic thrombocytopenic purpura (TTP)
- Wegener’s granulomatosis
Alagille syndrome mainly affects your liver but can damage other parts of your body including your kidneys, heart, brain, eyes, and skeleton. Learn more about Alagille syndrome.
Alport syndrome is caused by problems with three genes that control the way certain parts of your body are shaped. As a result, parts of your kidneys, ears, and eyes do not grow correctly. Learn more about Alport syndrome.
Amyloidosis (am-il-oyd-OH-sis) causes proteins called amyloids to build up and form clumps inside your organs and tissues, causing damage. Learn more about amyloidosis.
Cystinosis happens when cystine, a component of protein, builds up in your body’s cells. Having too much cystine can damage your organs including your kidneys, eyes, pancreas, liver, and brain. Learn more about cystinosis.
Fabry disease is caused by a gene mutation, and is passed down by parents to their children. With Fabry disease, there is a buildup of fat that causes your body’s cells to not work as they should. Learn more about Fabry disease.
Focal segmental glomerulosclerosis (FSGS)
Focal segmental glomerulosclerosis (FSGS) involves scars on some of your kidneys’ filters. The scarring makes it hard for your kidneys to filter out wastes from your body and can lead to kidney failure. Learn more about FSGS.
Glomerulonephritis (glow-mer-you-low-nef-RYE-tis), sometimes called glomerular disease, involves damage to the tiny filters in your kidneys, called glomeruli. Glomerulonephritis can begin suddenly or slowly, over time. Learn more about glomerulonephritis.
Goodpasture syndrome is a group of conditions that affects your kidneys and lungs. It causes your immune system to attack the tiny filters in your kidneys and the tissue in your lungs. Learn more about Goodpasture syndrome.
aHUS (atypical hemolytic uremic syndrome)
aHUS (atypical hemolytic uremic syndrome) is a rare disease that causes too many blood clots to form in your blood vessels. Because these blood clots block regular blood flow to your kidneys, your kidneys are not able to get rid of waste in your body as well as they should. Learn more about aHUS.
Hemolytic uremic syndrome (HUS)
Hemolytic uremic syndrome (HUS) occurs when your red blood cells are destroyed and block your kidneys’ filters. Learn more about HUS.
Henoch-Schönlein purpura (HSP) also known as anaphylactoid purpura, causes small blood vessels in your body including those in the skin, stomach, and kidneys to become swollen and leak. Learn more about Henoch-Schönlein purpura (HSP).
IgA nephropathy (Berger’s disease)
IgA is a protein that helps you fight infections. With IgA nephropathy, the IgA proteins build up and form clumps inside your kidneys’ tiny filters called glomeruli, and cause damage. Learn more about IgA nephropathy.
Interstitial nephritis happens when a part of your kidneys’ filters called the tubules become swollen. It can be acute, and only happen for a short time, or chronic, and last for several weeks or months. Learn more about interstitial nephritis.
Minimal change disease
Minimal change disease (MCD) involves damage to your kidneys’ tiny filters. The cause of MCD is unknown. Some suspected causes for MCD are allergic reactions, tumors, using NSAIDs, or infections. Learn more about minimal change disease (MCD).
Nephrotic syndrome is a group of symptoms that, together, indicate that your kidneys are not working as well as they should. Learn more about nephrotic syndrome.
Thrombotic thrombocytopenic purpura (TTP)
Thrombotic thrombocytopenic purpura (TTP), is a rare blood disease also known as microangiopathic hemolytic anemia, or Moschowitz disease. TTP happens when too many blood clots that have formed in your blood vessels make it hard for oxygen to reach organs in your body like the kidneys. Learn more about Thrombotic thrombocytopenic purpura (TTP).
Wegener’s granulomatosis, also known as granulomatosis with polyangiitis (GPA), is a disease that causes swelling and irritation of blood vessels in your kidneys, nose, sinuses, throat and lungs. Learn more about Wegener’s granulomatosis.